Which medications in the drug class Antibiotics are used in the treatment of Corneal Ulcer and Ulcerative Keratitis in Emergency Medicine?

Updated: Nov 08, 2018
  • Author: Jesse Borke, MD, FACEP, FAAEM; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Antibiotics

Therapy must cover all likely pathogens in the context of the clinical setting.

Cefazolin

First-generation cephalosporin antibiotic for gram-positive bacterial coverage. Commonly used in combination with an aminoglycoside to achieve broad-spectrum coverage.

This 50-133 mg/mL solution must be compounded.

Gentamicin (Gentak)

Aminoglycoside antibiotic used for gram-negative bacterial coverage. Commonly used in combination with a first-generation cephalosporin.

Erythromycin (PCE, Ery-Tab, Erythrocin Lactobionate, E.E.S.)

Indicated for treatment of infections caused by susceptible strains of microorganisms and for prevention of corneal and conjunctival infections.

Ciprofloxacin ophthalmic (Ciloxan)

Bactericidal antibiotic that inhibits bacterial DNA synthesis, and consequently growth, by inhibiting DNA gyrase in susceptible organisms.

Indicated for pseudomonal infections and those due to multidrug-resistant gram-negative organisms.


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