Which medications in the drug class Nonsteroidal anti-inflammatory agents (NSAIDs) are used in the treatment of Corneal Ulcer and Ulcerative Keratitis in Emergency Medicine?

Updated: Nov 08, 2018
  • Author: Jesse Borke, MD, FACEP, FAAEM; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Nonsteroidal anti-inflammatory agents (NSAIDs)

Mechanism of action is believed to be through inhibition of the cyclooxygenase enzyme that is essential in the biosynthesis of prostaglandins. Inhibition of prostaglandin synthesis results in vasoconstriction and decreases in vascular permeability, leukocytosis, and intraocular pressure (IOP). These agents, however, have no significant effect on IOP.

Ibuprofen (Addaprin, Caldolor, Genpril, Dyspel, Motrin, Advil)

Usually the DOC for treatment of mild to moderate pain, if no contraindications exist.

Inhibits inflammatory reactions and pain, probably by decreasing the activity of the enzyme cyclooxygenase, which results in prostaglandin synthesis.

Naproxen (Aleve, Naprosyn, Naprelan, Flanax Pain Relief, Anaprox DS)

Used for relief of mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing activity of the enzyme cyclooxygenase, resulting in prostaglandin synthesis.

Ketoprofen

Used for the relief of mild-to-moderate pain and inflammation. Small doses are initially indicated in small and elderly patients and in those with renal or liver disease. Doses >75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe patient for response.

Diclofenac (Cambia, Dyloject, Zipsor, Zorvolex)

Inhibits prostaglandin synthesis by decreasing activity of enzyme cyclo-oxygenase, which in turn decreases formation of prostaglandin precursors. Has anti-inflammatory, antipyretic, and analgesic properties.


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