What are the Caine diagnostic criteria for Wernicke encephalopathy (WE)?

Updated: Nov 20, 2018
  • Author: Philip N Salen, MD; Chief Editor: Andrew K Chang, MD, MS  more...
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The diagnostic sensitivity for the diagnosis of WE is optimized utilizing the Caine criteria. Sensitivity of the Caine criteria approaches 100% in patients with alcoholism without hepatic encephalopathy. The Caine criteria state that a diagnosis of WE should be considered in any patient with two of the following: nutritional deficiency, altered mental state or memory, oculomotor abnormalities, cerebellar dysfunction. [4]

After bariatric surgery it is recommended to follow up on thiamine status for at least 6 months. [1]

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