Which medications in the drug class Skeletal muscle relaxants are used in the treatment of Trigeminal Neuralgia in Emergency Medicine?

Updated: Oct 23, 2019
  • Author: Mityanand Ramnarine, MD, FACEP; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Skeletal muscle relaxants

These agents are useful in the treatment of TN, although not FDA-approved for this indication. They have CNS depressant properties as indicated by the production of sedation with somnolence, ataxia, and respiratory and cardiovascular depression. A recent review of nonepileptic drugs for trigeminal neuralgia concluded that there was insufficient evidence from randomized controlled trials to show significant benefit from nonantiepileptic drugs. [15]

Baclofen (Lioresal)

Most often used after therapy with carbamazepine has been initiated. Effects may be synergistic with those of carbamazepine. May induce hyperpolarization of afferent terminals and may inhibit both monosynaptic and polysynaptic reflexes at spinal level. As a structural analog of the inhibitory neurotransmitter GABA, may stimulate GABA-B receptor subtype.

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