What is the role of genetics in the etiology of delirium, dementia, and amnesia?

Updated: Sep 19, 2018
  • Author: Richard D Shin, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Answer

Early-onset familial Alzheimer's Disease, a rare subtype occurring in patients 30–60 years of age, is typically caused by an inherited mutation in one of three genes: chromosomes 21, 14 and 1. Transmission is autosomal dominant with a high degree of penetration. Other types of early-onset dementia have no known specific causes. Typical late-onset AD, first manifesting around the mid-sixties and older, may have some genetically inheritable risk, particularly involving the apolipoprotein E gene on chromosome 19. Researches have now identified many other areas of interest in the Alzheimer's genome that may prove to increase risk of developing the disease to varying degrees. [7]


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