How is pseudobulbar affect treated in patients with amyotrophic lateral sclerosis (ALS)?

Updated: Nov 13, 2019
  • Author: Kathleen Clem, MD, FACEP; Chief Editor: Andrew K Chang, MD, MS  more...
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Answer

Answer

Pseudobulbar affect, excessive laughing or crying or involuntary emotional expression, affects 20-50% of patients with ALS. [9] combined dextromethorphan and quinidine has been administered for this condition [10] . This drug combination was approved by the FDA in October 2010.


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