What is the role of riluzole in the treatment of amyotrophic lateral sclerosis (ALS)?

Updated: Jul 20, 2021
  • Author: Ryan Ghusayni, MD; Chief Editor: Andrew K Chang, MD, MS  more...
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Riluzole is the only current disease-specific medication approved by the US Food and Drug Administration (FDA) for use in patients with ALS. It should be prescribed only by a physician familiar with inclusion/exclusion criteria and who will be monitoring patient. It should not be prescribed in the ED acutely. [1, 4]

For patients who develop fatigue while taking riluzole, withholding the drug may be considered.

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