Which medications in the drug class Alpha-adrenergic antagonists are used in the treatment of Prostatitis?

Updated: Nov 01, 2019
  • Author: Paul J Turek, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Alpha-adrenergic antagonists

These agents are used in the treatment of benign prostatic hypertrophy. Studies suggest that combining alpha-blockers with antibiotics may reduce the risk of prostatitis recurrence in chronic prostatitis. Alpha-blockers reduce bladder outlet obstruction and thus improve voiding dysfunction that may be associated with prostatic swelling with prostatitis. Alpha-blockers may also have role to improve symptoms in chronic pelvic pain syndrome.


Quinazoline compound that counteracts alpha1-induced adrenergic contractions of bladder neck, terazosin facilitates urinary flow in the presence of prostate inflammation.

Tamsulosin (Flomax)

An alpha-adrenergic blocker, specifically targeting the A1 receptors, tamsulosin has the advantage of causing relatively less orthostatic hypotension, and it requires no gradual up-titration from the initial introductory dosage. On the other hand, a higher incidence of ejaculatory dysfunction exists with this medication (8.4-18.1%).

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