Which medications in the drug class Penicillins are used in the treatment of Breast Abscesses and Masses?

Updated: Jul 27, 2020
  • Author: Andrew C Miller, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Answer

Penicillins

Dicloxacillin

Outpatient therapy

Drug of choice (DOC) for mastitis. Bactericidal antibiotic that inhibits cell wall synthesis. Used to treat infections caused by penicillinase-­producing staphylococci. May be used to initiate therapy when a staphylococcal infection is suspected.

Amoxicillin/clavulanate (Augmentin, Augmentin ES-600, Augmentin XR)

Outpatient therapy

Amoxicillin binds to penicillin­-binding proteins, thus inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell walls; addition of clavulanate inhibits beta-­lactamase–producing bacteria, allowing amoxicillin extended spectrum of action

It is a semisynthetic antibiotic with a broad spectrum of bactericidal activity, covering both gram-­negative and gram-­positive microorganisms.

Nafcillin

Inpatient therapy

DOC for puerperal breast abscess. Used to treat infections caused by penicillinase-­producing staphylococci. Used to initiate therapy when a penicillin G–resistant staphylococcal infection is suspected.

Because of occasional occurrence of thrombophlebitis associated with parenteral route (particularly in elderly persons), administer parenterally only for a short term (24-­48 hours) and change to a PO equivalent, if clinically possible.

Oxacillin (Bactocill)

Inpatient therapy

Bactericidal antibiotic that inhibits cell wall synthesis. Used in the treatment of infections caused by penicillinase­-producing staphylococci. May be used to initiate therapy when a staphylococcal infection is suspected.

Ampicillin/sulbactam (Unasyn)

Inpatient therapy

Alternative DOC for nonpuerperal breast abscess. Drug combination that utilizes a beta-­lactamase inhibitor with ampicillin.

Covers skin, enteric flora, and anaerobes. Not ideal for nosocomial pathogens.


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