Which medications in the drug class Oxazolidinones are used in the treatment of Breast Abscesses and Masses?

Answer

Oxazolidinones

Linezolid (Zyvox)

Inpatient or outpatient treatment

If MRSA risk with beta-lactam allergy.

Binds to bacterial 23S rRNA of the 50S subunit to prevent protein translation; also elicits nonselective MAO inhibition.

Caution: Pregnancy category C; secreted in breast milk, use caution if used while breastfeeding.

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Media Gallery

Ultrasonogram demonstrates a hypoechoic mass with smooth, partially lobulated margins typical of a fibroadenoma.
Craniocaudal mammograms obtained 1 year apart demonstrate a newly developing mass in the outer part of the breast.
Spot compression mammogram of the outer part of the breast demonstrates a new mass as smooth, margined, and oval. The findings are consistent with a fibroadenoma, a cyst, or a malignancy. In this patient, the diagnosis was a rapidly growing fibroadenoma.
Eggshell or rim calcifications (arrows) have walls thinner than those of lucent-centered calcifications.
This mass with associated large, coarse calcifications (arrows) is a degenerating fibroadenoma.
Breast cancer, ultrasonography. Mediolateral oblique digital mammogram of the right breast in a 66-year-old woman with a new, opaque, irregular mass approximately 1 cm in diameter. The mass has spiculated margins in the middle third of the right breast at the 10-o'clock position. Image demonstrates both the spiculated mass (black arrow) and separate anterior focal asymmetry (white arrow).
Breast cancer, ultrasonography. Antiradial sonogram of the spiculated mass (shown in the image above) demonstrates a hypoechoic mass with angular margins (black arrows). Cursors on the margins of the mass were used to electronically measure its dimensions of the mass, which was 0.9 X 0.8 cm.
Breast cyst. A) A simple, fairly round breast cyst with hypo or anechoic contents and well-defined borders; B) Posterior acoustic enhancement is seen as well as edge shadows (arrows).
Breast adenoma. A) A breast adenoma is oval with well-defined borders. It may be hypoechoic and some internal echogenicity may be seen. It is wider than tall and posterior acoustic enhancement is NOT seen, helping distinguish from a cyst or other fluid collection. B) An arrow indicates the adenoma.
Breast hematoma. A) A breast hematoma is seen as a round echogenic collection with surrounding tissue edema. A hematoma may be hypoechoic, mixed, or fairly echogenic depending on the stage of the hematoma. B) The hematoma is outlined and tissue edema noted.
Loculated breast abscess. A) A large loculated abscess is seen containing hypoechoic fluid and some internal echoes. Posterior acoustic enhancement is seen. Care must be taken to image at an adequate depth to visualize posterior borders of breast lesions. B) The abscess is outlined in yellow and the posterior acoustic enhancement is noted.
Loculated breast abscess, curvilinear. A) This is the same abscess seen in the above image and is imaged with a curvilinear transducer to better appreciate the extent of the abscess. It is important to image the abscess completely for width and depth. B) The abscess is outlined in yellow and the ribs and posterior acoustic enhancement are noted.
Purulent breast abscess. A) A purulent breast abscess is seen. The fluid is echogenic, but can be recognized as a disruption of the surrounding tissue and posterior acoustic enhancement. B) The abscess is outlined in yellow and the posterior acoustic enhancement is noted.
Complex breast abscess. In this clip, the features of a loculated breast abscess containing echogenic purulent material are noted. Example of imaging with a linear high-frequency transducer.
Loculated breast abscess, curvilinear. In this clip, a large, loculated breast abscess and its features are noted. Example of imaging with a lower-frequency curvilinear transducer to better appreciate the extent of this large abscess.

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Author

Andrew C Miller, MD Director of Research, Department of Emergency Medicine, Nazareth Hospital, Philadelphia College of Osteopathic Medicine

Andrew C Miller, MD is a member of the following medical societies: American College of Academic International Medicine, American College of Emergency Physicians, American College of Physicians, American Medical Association, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Coauthor(s)

Phanniram B Sumanam, MD Resident Physician, Department of Emergency Medicine, Nazareth Hospital; Hospitalist, Fox Chase Cancer Center, Abington Hospital-Jefferson Health, and Nazareth Hospital

Phanniram B Sumanam, MD is a member of the following medical societies: American College of Emergency Physicians, American College of Physicians, American Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Barry J Sheridan, DO Chief Warrior in Transition Services, Brooke Army Medical Center

Barry J Sheridan, DO is a member of the following medical societies: American Academy of Emergency Medicine

Disclosure: Nothing to disclose.

Chief Editor

Jeter (Jay) Pritchard Taylor, III, MD Assistant Professor, Department of Surgery, University of South Carolina School of Medicine; Attending Physician, Clinical Instructor, Compliance Officer, Department of Emergency Medicine, Palmetto Richland Hospital

Jeter (Jay) Pritchard Taylor, III, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Columbia Medical Society, Society for Academic Emergency Medicine, South Carolina College of Emergency Physicians, South Carolina Medical Association

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Employed contractor - Chief Editor for Medscape.

Additional Contributors

Caitlin Kennedy, MD Resident Physician, Department of Emergency Medicine, West Virginia University School of Medicine

Caitlin Kennedy, MD is a member of the following medical societies: American College of Emergency Physicians, American Medical Association, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

John W Hall, IV West Virginia University School of Medicine

John W Hall, IV is a member of the following medical societies: American Medical Association, American Medical Student Association/Foundation, Phi Beta Kappa

Disclosure: Nothing to disclose.

Suha Abdulkarim Khafaji, MBBS Research Physician, Department of Emergency Medicine, West Virginia University School of Medicine

Disclosure: Nothing to disclose.

Joseph J Minardi, MD Associate Professor, Department of Emergency Medicine, Department of Medical Education, West Virginia University School of Medicine; Director of Emergency Ultrasound, Department of Emergency Medicine, West Virginia University Hospitals

Joseph J Minardi, MD is a member of the following medical societies: Academy of Emergency Ultrasound, American College of Emergency Physicians, American Institute of Ultrasound in Medicine, American Medical Association, American Registry for Diagnostic Medical Sonography, American Society of Echocardiography, Emergency Ultrasound Fellowship, Society for Academic Emergency Medicine, Society of Ultrasound in Medical Education

Disclosure: Nothing to disclose.

Alexandra R King, PharmD, DABAT Clinical Pharmacist, Emergency Medicine and Toxicology, Vidant Medical Center

Alexandra R King, PharmD, DABAT is a member of the following medical societies: American Academy of Clinical Toxicology, American College of Clinical Pharmacy, Society of Critical Care Medicine

Disclosure: Nothing to disclose.

Celia Escamilla, MD Resident Physician, Department of Emergency Medicine, Vidant Medical Center, The Brody School of Medicine at East Carolina University

Disclosure: Nothing to disclose.

Dalal H Alsaggabi, MD Postdoctoral Research Scientist/Fellow, Langone Medical Center, New York University School of Medicine

Disclosure: Nothing to disclose.

Acknowledgements

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors, Sadia Hussain, MD, Tajinderpal Saraon, MD, Mark Silverberg, MD, Howard A Blumstein, MD, and Amy K Rontal, MD, to the development and writing of this article.

Which medications in the drug class Oxazolidinones are used in the treatment of Breast Abscesses and Masses?

Oxazolidinones

Linezolid (Zyvox)

Related Questions:

References

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