What is the pathophysiology of breast abscesses and masses?

Updated: Jul 27, 2020
  • Author: Andrew C Miller, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Answer

The mammary glands arise from a caudal section of the ectodermal tissue known as the “milk lines,” which extend along the anterior surface of the developing fetus from the axilla to the groin. During puberty, pituitary and ovarian hormonal influences stimulate female breast enlargement, primarily owing to accumulation of adipocytes. Each breast contains approximately 15-25 glandular units known as breast lobules, which are demarcated by Cooper ligaments. Each lobule is composed of a tubuloalveolar gland and adipose tissue. Each lobule drains into the lactiferous duct, which subsequently empties onto the surface of the nipple. Multiple lactiferous ducts converge to form one ampulla, which traverses the nipple to open at the apex. [5]

Below the nipple surface, lactiferous ducts form large dilations called lactiferous sinuses, which act as milk reservoirs during lactation. [6] When the lactiferous duct lining undergoes epidermalization, keratin production may cause plugging of the duct, resulting in abscess formation. [7, 8] This may explain the high recurrence rate (an estimated 39%-50%) of breast abscesses in patients treated with standard incision and drainage, as this technique does not address the basic mechanism by which breast abscesses are thought to occur.

Postpartum mastitis is a localized cellulitis caused by bacterial invasion through an irritated or fissured nipple. It typically occurs after the second postpartum week and may be precipitated by milk stasis. [9] There is usually a history of a cracked nipple or skin abrasion or failure to clean nipples after breastfeeding. [10] Sleeping position may also affect the progression of mastitis to breast abscess. [10] Staphylococcus aureus is the most common organism responsible, but Staphylococcus epidermidis and streptococci are occasionally isolated. Drainage of milk from the affected segment should be encouraged and is best achieved by continued breastfeeding or use of a breast pump. [3, 8, 4]

Nonlactating infections may be divided into central (periareolar) and peripheral breast lesions. Periareolar infections consist of active inflammation around nondilated subareolar breast ducts—a condition termed periductal mastitis. Peripheral nonlactating breast abscesses are less common than periareolar abscesses and are often associated with an underlying condition such as diabetes, rheumatoid arthritis, steroid treatment, granulomatous lobular mastitis, trauma, and smoking. [1, 11, 12] Primary skin infections of the breast (cellulitis or abscess) most commonly affect the skin of the lower half of the breast and often recur in women who are overweight, have large breasts, or have poor personal hygiene. [3]

Breast masses can involve any of the tissues that make up the breast, including overlying skin, ducts, lobules, and connective tissues. Fibrocystic disease, the most common breast mass in women, is found in 60%-90% of breasts during routine autopsy. Fibroadenoma, the most common benign tumor, typically affects women aged 30 years or younger and accounts for 91% of all solid breast masses in females younger than 19 years. [5] Infiltrating ductal carcinoma is the most common malignant tumor; however, inflammatory carcinoma is the most aggressive and carries the worst prognosis. Mammary Paget disease, or adenocarcinoma of the nipple epidermis, is relatively rare but may be misdiagnosed as a benign dermatosis if care is not taken. [13, 14]


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