Which disorders should be included in the differential diagnoses for immune thrombocytopenia (ITP)?

Updated: Dec 14, 2019
  • Author: Michael A Silverman, MD, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Answer

Other problems to be considered in the differential diagnosis include the following:

  • Pseudothrombocytopenia (platelet clumping in the presence of ethylenediaminetetraacetic acid [EDTA])

  • Liver disease

  • Myelodysplasia

  • Lymphoproliferative, autoimmune, or infectious diseases

  • Pregnancy-associated thrombocytopenia

  • Drug-induced immune thrombocytopenia (alcohol, heparin, quinine/quinidine, sulfonamides)

  • Infection/sepsis

  • Acute leukemia

  • Myelodysplastic syndrome

  • Malignancy

  • Megaloblastic anemia

  • Isoimmune neonatal purpura

  • Transfusion

  • Factitious


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