Which medications in the drug class Factor IX-containing Products are used in the treatment of Hemophilia B?

Updated: Oct 02, 2020
  • Author: Robert A Zaiden, MD; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Answer

Factor IX-containing Products

These agents are used to correct the patient's native deficiency, with the goals of achieving a normal hematologic response to hemorrhage or preventing hemorrhage. Fresh frozen plasma is no longer used in hemophilia because of the lack of safe viral elimination and concerns regarding volume overload.

Factor IX, recombinant (BeneFIX, Rixubis, Alprolix, Ixinity, Rebinyn)

Recombinant factor IX (rFIX) uses no human products for stabilization. Each of the brands is FDA-approved for control and prevention of bleeding episodes, and for perioperative management in adults and children. Rixubis, Ixinity, and Alprolix are also approved for routine prophylaxis in adults and children. Alprolix is a long-acting product, it may be administered for routine prophylaxis once weekly or every 10 days. Rebinyn is a glycopegylated long-acting rFIX. Pegylation slows removal of FIX from the blood circulation.

Factor IX, recombinant/albumin fusion protein (Idelvion)

Recombinant protein that temporarily replaces missing coagulation Factor IX needed for effective hemostasis. Comprised of genetically fused recombinant coagulation Factor IX and recombinant albumin, which extends the half-life of Factor IX. It is indicated for on-demand control and prevention of bleeding episodes, management of postoperative bleeding, and as prophylaxis to reduce the frequency of bleeding episodes.

Factor IX (Mononine, AlphaNine SD)

Human blood-derived Factor IX indicated for control and prevention of bleeding episodes, and for perioperative management in adults and children.

Factor IX Complex (Bebulin, Bebulin VH, Profilnine SD)

Human plasma-derived prothrombin complex concentrates. These pooled plasma products (high purity) replace deficient FIX and other coagulation factors.


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