Which medications in the drug class Vasopressin-Related are used in the treatment of Hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Vasopressin-Related

Desmopressin transiently increases the FVIII plasma level in patients with mild hemophilia A.

Desmopressin (DDAVP, Stimate)

Desmopressin causes a transient increase (up to 4-fold) in FVIII plasma levels of patients with mild hemophilia A. It also produces a dose-dependent increase in plasminogen activator. It is useful for minor hemorrhage episodes only. It may be useful in patients with FVIII inhibitors.

Desmopressin Increases the cellular permeability of the collecting ducts, resulting in renal reabsorption of water. Tachyphylaxis may occur even after first dose, but drug can be effective again after several days.


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