What are the dosing regimen used for immune tolerance induction (ITI) in the treatment of hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

The choice of FVIII dosing regimen for ITI has ranged from 50 IU/kg 3 times weekly to 300 IU/kg/d. An international study in patients with severe hemophilia and high-titer inhibitors found no significant difference between low-dose and high-dose ITI in terms of the percentage of subjects achieving tolerance (70%) or in the time taken to achieve tolerance. However, the study was stopped early because of safety considerations involving bleeding (significantly more common early on in the low-dose arm) and lack of statistical power. [40]


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