Which factors are associated with successful outcome of immune tolerance induction (ITI) in the treatment of hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In ITI, tolerance to FVIII is induced by means of regular exposure to FVIII over several months to years. [29, 39] The overall likelihood of success with ITI is 70% ± 10%.

Factors associated with successful outcome of ITI include the following [40] :

  • Historical inhibitor titers < 200 BU and immediate pre-ITI titers < 10 BU

  • Younger age at ITI initiation

  • An interval of < 5 years between inhibitor diagnosis and ITI start

  • ITI interruption < 2 weeks in duration


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