What are alternative treatment options for hemophilia A with factor VIII (FVIII) inhibitors?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Other approaches to treating patients with FVIII inhibitors include the following:

  • Porcine FVIII, which has low cross-reactivity with human FVIII antibody

  • Activated prothrombin complex concentrate (PCC)

  • Activated FVII

  • Desensitization

  • Immune tolerance induction (ITI)

  • Monoclonal antibodies that bridge FIXa and FX (eg, emicizumab)


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