What are alternative treatment options for hemophilia A with factor VIII (FVIII) inhibitors?

Updated: Jun 05, 2020
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Other approaches to treating patients with FVIII inhibitors include the following:

  • Porcine FVIII, which has low cross-reactivity with human FVIII antibody
  • Activated prothrombin complex concentrate (aPCC)
  • Activated recombinant FVII (rFVIIa)
  • Desensitization
  • Immune tolerance induction (ITI)
  • Monoclonal antibodies that bridge FIXa and FX (eg, emicizumab)

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