What are adverse effects of desmopressin vasopressin analog for hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Hyponatremia due to water retention is a potentially serious adverse effect. Patients should be advised to limit water intake for approximately 12-18 hours after the administration of DDAVP, until the antidiuretic effect passes, and should avoid three consecutive daily doses. In addition, patients should be alerted to the distinct drop in urine output they will experience after DDAVP administration, and the subsequent increase when the antidiuretic effect of DDAVP wanes.

Tachyphylaxis may occur even after first dose, but the drug can be effective again after several days. A minor adverse effect of DDAVP is facial flushing.


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