What is the indication for continuous infusion of factor VIII (FVIII) concentrates in the treatment of hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Besides improved hemostasis, continuous infusion decreases the amount of factor used, which can result in significant savings. The indications for this approach include the following:

  • Intracranial hemorrhage
  • Vascular compromise
  • Iliopsoas bleeding
  • Preparation for surgery

In most minor-to-moderate bleeding episodes, intermittent boluses are adequate. Intermittent boluses can also be used prophylactically, especially in the treatment of recurrent bleeding in target joints.


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