Which treatments are used for hemophilia A in patients with inhibitors of factor VIII (FVIII)?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Treatments used in patients with inhibitors of FVIII are as follows:

  • High doses of FVIII for low-titer inhibitors

  • Activated prothrombin complex concentrate (aPCC)

  • Activated recombinant FVII (rFVIIa)

  • Monoclonal antibodies directed toward restoring FVIII function (eg, emicizumab)

  • Porcine FVIII, which has low cross-reactivity with human FVIII antibody

  • Desensitization

  • Immune tolerance induction (ITI)

See Treatment and Medication for more detail.


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