What types of factor VIII (FVIII) are available for the treatment of hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

The following types of FVIII concentrates are available:

  • Plasma-based products: Purified to inactivate viruses

  • First-generation recombinant products: Produced in mammalian cell lines, contain animal and/or human plasma-derived proteins in cell culture media and in final product.

  • Second-generation recombinant products:  Produced in mammalian cell lines, contain animal and/or human plasma-derived proteins in cell culture media but none in final product.

  • Third-generation recombinant products: Produced in mammalian cell lines, contain no animal and/or human plasma-derived proteins in cell culture media or in final product.

  • Extended half-life recombinant FVIII products


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