What are the possible regimens for factor VIII (FVIII) dosing in hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

FVIII regimens are as follows:

  • The second dose should be administered 8-12 hours after the initial dose and is usually one half the initial calculated dose

  • Minor hemorrhage requires 1-3 doses of FVIII

  • Major hemorrhage requires many doses and continued FVIII activity monitoring with the goal of keeping the trough activity level at least 50%

  • Continuous infusions of FVIII may be considered for major hemorrhage or major surgery


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