How is the number of units of factor VIII needed to correct the factor VIII activity level in hemophilia A determined?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Ideally, therapy is individualized to specific patients.  However, for general dosing, to find the number of units of factor VIII needed to correct the factor VIII activity level, use the following formula:

Dose in FVIII IU = (weight in kg) x (desired FVIII increase) x (0.5 IU/kg per IU/dL)


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