What are the treatment options for acute bleeds in hemophilia A?

Updated: Jan 14, 2019
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

For treatment of acute bleeds, target levels by hemorrhage severity are as follows:

  • Mild hemorrhages (eg, early hemarthrosis, epistaxis, gingival bleeding): Maintain an FVIII level of 30%

  • Major hemorrhages (eg, late hemarthrosis, muscle bleeds): Maintain an FVIII level of at least 50%

  • Life- or limb-threatening bleeding episodes (eg, major trauma or surgery, advanced or recurrent hemarthrosis, major GI bleeding, any head trauma, signs of distal neurovascular compormise of limb or compartment syndrome): Maintain an FVIII level of 80-100%


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