What are the signs and symptoms of hemophilia A?

Updated: Jun 05, 2020
  • Author: Douglass A Drelich, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Depending on the level of FVIII activity, patients with hemophilia may present with easy bruising; inadequate clotting of traumatic or even mild injury; or, in the case of severe hemophilia, spontaneous hemorrhage.

Signs of hemorrhage include the following:

  • General (usuall attributed to anemia secondary to bleeding): Weakness, orthostasis, tachycardia, tachypnea

  • Musculoskeletal (joints): Tingling, cracking, warmth, pain, stiffness, and refusal to use joint (children)

  • CNS: Headache, stiff neck, vomiting, lethargy, irritability, and spinal cord syndromes

  • Gastrointestinal: Hematemesis, melena, frank red blood per rectum, and abdominal pain

  • Genitourinary: Hematuria, renal colic, and post circumcision bleeding

  • Other: Epistaxis, oral mucosal hemorrhage, hemoptysis, dyspnea (hematoma leading to airway obstruction), compartment syndrome symptoms, and contusions; excessive/prolonged bleeding with routine dental or other procedures

See Presentation for more detail.

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