What is the hyaluronidase method for the treatment of paraphimosis?

Updated: Aug 05, 2017
  • Author: Hina Z Ghory, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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The puncture method can be enhanced by the injection of 1-mL aliquots of hyaluronidase (using a tuberculin syringe) into one or more sites of the edematous prepuce. It is thought that hyaluronidase disperses extracellular edema by modifying the permeability of intercellular substance in connective tissue. The use of this method is contraindicated in those with the presence of infection or cancer, since the technique may result in the spread of bacteria or malignant cells. Drawbacks to this method include the risk of anaphylaxis and shock and the lack of availability of hyaluronidase in many EDs.

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