Which medications in the drug class Antibiotics are used in the treatment of Orchitis?

Updated: Aug 16, 2017
  • Author: Nataisia Terry, MD; Chief Editor: Erik D Schraga, MD  more...
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Therapy must cover all likely pathogens in the context of the clinical setting.

Ceftriaxone (Rocephin)

Third-generation cephalosporin with broad-spectrum, gram-negative activity; lower efficacy against gram-positive organisms; higher efficacy against resistant organisms. Arrests bacterial growth by binding to one or more penicillin-binding proteins. Used because of an increasing prevalence of penicillinase producing Neisseria gonorrhoeae.

Doxycycline (Vibramycin, Doryx)

Inhibits protein synthesis and bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.

Used in combination with ceftriaxone for the treatment of gonorrhea.

Azithromycin (Zithromax)

Treats mild-to-moderate infections caused by susceptible strains of microorganisms.

Indicated for chlamydia and gonorrheal infections of the genital tract.

Trimethoprim/sulfamethoxazole (Bactrim DS, Septra DS)

Inhibits bacterial growth by inhibiting synthesis of dihydrofolic acid. Commonly used in patients >35 y with orchitis.

Ofloxacin (Floxin)

Penetrates prostate well and is effective against C trachomatis. A pyridine carboxylic acid derivative with broad-spectrum bactericidal effect. Used commonly in patients >35 y diagnosed with orchitis.

Ciprofloxacin (Cipro)

Fluoroquinolone with activity against pseudomonads, streptococci, MRSA, S epidermidis, and most gram-negative organisms, but no activity against anaerobes. Inhibits bacterial DNA synthesis and consequently growth. Continue treatment for at least 2 d (7-14 d typical) after signs and symptoms have disappeared. Used commonly in patients >35 y diagnosed with orchitis.

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