Which medications in the drug class Calcium Channel Blockers are used in the treatment of Anal Fistulas and Fissures?

Updated: Nov 09, 2018
  • Author: Bruce M Lo, MD, MBA, CPE, RDMS, FACEP, FAAEM, FACHE; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Calcium Channel Blockers

Calcium channel blockers work by decreasing resting anal pressures. In a recent review, calcium channel blockers were shown to be as effective as topical nitrates. Oral and topical calcium channel blockers (diltiazem and nifedipine) have been shown to be effective treatment options for anal fissures.

Nifedipine (Nifediac CC, Adalat CC, Procardia, Procardia XL)

Nifedipine is the prototypical dihydropyridine. The topical form is preferred but must be compounded in the pharmacy.

Diltiazem (Cardizem, Cardizem CD, Cartia XT, Dilacor XR, Tiazac)

Diltiazem is a nondihydropyridine that has been reported to be effective. The topical form is preferred but must be compounded in the pharmacy.


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