What is the role of botulinum toxin in the treatment of anal fissures?

Updated: Nov 09, 2018
  • Author: Bruce M Lo, MD, MBA, CPE, RDMS, FACEP, FAAEM, FACHE; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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A systematic review (inception to March 2017) and meta-analysis of 6 randomized controlled trials comprising 393 patients with chronic anal fissue found fewer side effects with botulinum toxin than with topical nitrates, but there were no significant differences in incomplete fissue healing or recurrence. [18]

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