What is the efficacy of switching from IV to oral antibiotics in the treatment of acute cholangitis?

Updated: Dec 29, 2017
  • Author: Timothy M Scott, DO; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

In addition, a study by Park et al indicated that in patients with acute cholangitis with bacteremia who have achieved successful biliary drainage, treatment with an early switch from intravenous to oral antibiotics is just as effective as conventional 10-day intravenous antibiotic therapy. The study involved 59 patients, including 30 who underwent conventional intravenous antibiotic treatment and 29 who were switched early in treatment to oral antibiotics. At follow-up, 30 days after diagnosis, the investigators determined that the bacterial eradication rate was not significantly different between the two groups, being 93.3% for the conventional treatment patients and 93.1% for the early switch group. Moreover, the groups showed no statistically significant differences in the recurrence rate for acute cholangitis and the 30-day mortality rate. [22]


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