Which medications in the drug class Antiemetic are used in the treatment of Small-Bowel Obstruction?

Updated: Apr 28, 2017
  • Author: Mityanand Ramnarine, MD, FACEP; Chief Editor: Steven C Dronen, MD, FAAEM  more...
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These agents should be administered for symptomatic relief, usually in conjunction with GI decompression via placement of an NG tube for suction.

Promethazine (Phenergan, Phenadoz, Promethegan)

Promethazine is for the symptomatic treatment of nausea and vomiting. It is an antidopaminergic agent that is effective in treating emesis. Promethazine blocks postsynaptic mesolimbic dopaminergic receptors in the brain and reduces stimuli to the brainstem reticular system.

Ondansetron (Zofran, Zuplenz)

Ondansetron is a selective 5-HT3-receptor antagonist that blocks serotonin peripherally and centrally; it is used in the prevention of nausea and vomiting. Ondansetron is metabolized in the liver through the P-450 pathway.

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