Which medications in the drug class Corticosteroids are used in the treatment of Smoke Inhalation Injury?

Updated: Oct 15, 2021
  • Author: Keith A Lafferty, MD; Chief Editor: Joe Alcock, MD, MS  more...
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Answer

Corticosteroids

Whether corticosteroids are beneficial in toxic smoke inhalation is a matter of some debate, but many experts consider these agents helpful in this setting. Corticosteroids are considered especially useful in metal fume fever, which is believed to be mediated by an inflammatory cascade of events involving cytokines and histamine release.

Methylprednisolone (Medrol, Depo-Medrol, Solu-Medrol, A-Methapred)

Methylprednisolone decreases inflammation by suppressing the migration of polymorphonuclear neutrophils (PMNs) and reversing increased capillary permeability.

Dexamethasone (Dexamethasone Intensol)

Dexamethasone decreases immune reactions. It provides a local anti-inflammatory effect while minimizing some of the gastrointestinal and other risks associated with systemic medications. Dexamethasone suppresses the migration of polymorphonuclear leukocytes (PMNs) and reduces capillary permeability.


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