What are the indications for hyperbaric oxygen (HBO) therapy in the treatment of smoke inhalation injury?

Updated: Oct 15, 2021
  • Author: Keith A Lafferty, MD; Chief Editor: Joe Alcock, MD, MS  more...
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Answer

Neurologic abnormalities and a history of loss of consciousness are the primary clinical features used to define severe CO toxicity and are indications for hyperbaric oxygen (HBO) therapy. In addition, HBO use is indicated in patients with any of the following:

  • Base excess lower than -2 mmol/L

  • CO level greater than 25% (or >15% in pregnancy, as fetal hemoglobin binds CO more tightly)

  • Signs of cerebellar dysfunction

  • Cardiovascular dysfunction

  • Pulmonary edema

  • Extremes of age

See Treatment and Medication for more detail.


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