Which medications in the drug class Antihistamines are used in the treatment of Insect Bites?

Updated: Jun 21, 2018
  • Author: Boyd (Bo) D Burns, DO, FACEP, FAAEM; Chief Editor: Joe Alcock, MD, MS  more...
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These agents prevent histamine response in sensory nerve endings and blood vessels; they are more effective in preventing histamine response than in reversing it. H2 antihistamines are useful in treatment of anaphylactic reactions when used concomitantly with H1 antagonists. Many H2 blockers are available. Cimetidine is the prototype drug.

Diphenhydramine (Benadryl)

Diphenhydramine is used for symptomatic relief of allergic symptoms caused by histamines released in response to allergens. There are many effective H1 blockers; diphenhydramine is effective and widely available.

Cimetidine (Tagamet)

Cimetidine is an H2 antagonist that, when combined with H1 type, may be useful to treat itching and flushing in anaphylaxis, pruritus, urticaria, and contact dermatitis that do not respond to H1 antagonists alone. Use it in addition to H1 antihistamines.

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