Which medications in the drug class ADH replacement therapy are used in the treatment of Hypernatremia in Emergency Medicine?

Updated: Mar 17, 2020
  • Author: Zina Semenovskaya, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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ADH replacement therapy

This therapy reduces free water loss and concentrates the urine.

Vasopressin (Pitressin)

Has vasopressor and ADH activity. Increases water resorption at the distal renal tubular epithelium (ADH effect) and promotes smooth muscle contraction throughout the vascular bed of the renal tubular epithelium (vasopressor effects). Vasoconstriction also is increased in splanchnic, portal, coronary, cerebral, peripheral, pulmonary, and intrahepatic vessels. Decreases portal pressure in patients with portal hypertension. A notable undesirable effect is coronary artery constriction, which may dispose patients with coronary artery disease to cardiac ischemia. This can be prevented with concurrent use of nitrates. Duration of action is approximately 3-6 h. Short half-life lessens the risk of acute water intoxication and makes it the ideal treatment of central DI in emergent situations.

Desmopressin acetate (DDAVP)

Increases cellular permeability of collecting ducts, resulting in reabsorption of water by the kidneys. Duration of action is approximately 12-24 h. Has become the long-term treatment of choice for central DI.

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