What is the prognosis of hypercalcemia associated with malignancy?

Updated: Apr 29, 2020
  • Author: Thomas E Green, DO, MPH, MMM, CPE, FACEP, FACOEP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Prognosis of hypercalcemia associated with malignancy is poor; the 1-year survival rate is 10-30%. In one study, 50% of patients died within 30 days of beginning treatment; 75% died within 3 months.

In a study by Ramos et al of patients with solid tumors suffering from malignancy-related hypercalcemia, univariable analysis showed significantly poorer survival in those with an Eastern Cooperative Oncology Group performance status of over 2, altered mental status, a C-reactive protein level above 30 mg/L, an albumin concentration of less than 2.5 g/dL, or a body mass index below 18 kg/m2. [15]

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