Which medications in the drug class Antibiotics are used in the treatment of Retropharyngeal Abscess?

Updated: Jan 08, 2021
  • Author: Joseph H Kahn, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Gram-positive organisms (including beta-lactamase – producing microbes), gram-negative organisms, and anaerobes must be covered. The Sanford Guide to Antimicrobial Therapy recommends adding empiric vancomycin to the regimen if the patient is in a high-risk group. [11]

In a review of retropharyngeal infections in children, Wald recommended adding vancomycin or linezolid to the regimen in patients who do not respond to clindamycin and in those who present with severe disease, in order to cover MRSA. [4]


Empiric Therapy (does not address possible infection with S aureus or P aeruginosa) [11] :

Ceftriaxone + metronidazole

Levofloxacin + clindamycin



Directed/Specific Therapy [11] :

     Positive culture or high risk for S aureus:

            add vancomycin

     Positive culture of high risk for P aeruginosa:


            Cefepime + metronidazole

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