What are the characteristics of group A streptococcal (GAS) pharyngitis (strep throat)?

Updated: May 06, 2020
  • Author: John R Acerra, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Streptococcal infections are characterized by local invasion and release of extracellular toxins and proteases. In addition, M protein fragments of certain serotypes of GAS are similar to myocardial sarcolemma antigens and are linked to rheumatic fever and subsequent heart valve damage. The prevalence rates of these serotypes of GAS have been becoming rarer over the past several years. Acute glomerulonephritis may result from antibody-antigen complex deposition in glomeruli. [4]

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