Which medications in the drug class Analgesic-antipyretics are used in the treatment of Epiglottitis?

Updated: Apr 28, 2020
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Analgesic-antipyretic agents are helpful in relieving the lethargy, malaise, and fever associated with epiglottitis.

Aspirin (Anacin, Aspercin, Bayer Aspirin)

Aspirin blocks prostaglandin synthetase action, which, in turn, inhibits prostaglandin synthesis and prevents the formation of platelet-aggregating thromboxane A2. This agent acts on the hypothalamus heat-regulating center to reduce fever. The dissipation of heat is enhanced by vasodilation of the peripheral vessels, causing a decrease in body temperature.

Acetaminophen (Tylenol, Acephen, Aspirin-Free Anacin)

Acetaminophen is the drug of choice (DOC) for treating pain in patients with documented hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), those with upper gastrointestinal disease, or those who take oral anticoagulants. This agent reduces fever by a direct action on the hypothalamic heat-regulating centers, which increases dissipation of body heat via vasodilation and sweating.

Ibuprofen (NeoProfen, Advil, Motrin)

Ibuprofen is usually the drug of choice (DOC) for treating mild to moderate pain, if no contraindications exist. This agent inhibits inflammatory reactions and pain, probably by decreasing the activity of the cyclooxygenase enzyme, which inhibits prostaglandin synthesis. Ibuprofen is one of the few nonsteroidal anti-inflammatory drugs (NSAIDs) that is indicated for reduction of fever.

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