Which pathologic and histologic findings are characteristic of atopic dermatitis (AD)?

Updated: Apr 26, 2021
  • Author: Cassandra Bradby, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Pathologic findings of biopsy samples include spongiosis with a severely damaged stratum corneum, with hyperproliferation in advanced cases.

Histological studies show an inflammatory infiltrate consisting of memory predominantly CD4 T lymphocytes. Chronic lesions also display increased mast cells, eosinophils, and IgE-bearing Langerhans cells.


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