What are the Hanifin and Rajka diagnostic criteria for atopic dermatitis (AD)?

Updated: Apr 26, 2021
  • Author: Cassandra Bradby, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Major criteria (need 3 or more) are as follows:

  • Pruritus

  • Typical morphology and distribution

  • Flexural lichenification in adults

  • Facial and extensor involvement in infants and children

  • Dermatitis - Chronically or chronically relapsing

  • Personal or family history of atopy (asthma, allergic rhinitis, atopic dermatitis)

Minor criteria (need 3 or more) are as follows:

  • Cataracts

  • Cheilitis

  • Conjunctivitis - Recurrent

  • Eczema - Perifollicular accentuation

  • Facial pallor or erythema

  • Hand dermatitis - Nonallergic

  • Ichthyosis

  • IgE - Elevated

  • Immediate (type I) skin test reactivity

  • Infections (cutaneous)

  • Dennie-Morgan infraorbital fold

  • Itching when sweating

  • Nipple dermatitis

  • Orbital darkening

  • Palmar hyperlinearity

  • White dermographism

  • Wool intolerance

  • Xerosis


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