What are the clinical findings of the O’Brien et al study related to the efficacy of brain natriuretic peptide (BNP) assays?

Updated: Jan 08, 2018
  • Author: Donald Schreiber, MD, CM; Chief Editor: Erik D Schraga, MD  more...
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In contrast to previous studies, this report, which looked at 96 patients who were hospitalized for exacerbation of CHF, did not reveal a statistically significant relationship between the admission NT-proBNP level and outcome. However, the discharge NT-proBNP level was a statistically significant predictor of adverse outcome.

In the study, a group from the United Kingdom assessed the predictive value of admission NT-proBNP levels compared with discharge levels in predicting adverse outcomes. [53] NT-proBNP values were measured in all patients on admission and in 34 patients at discharge. Outcome measures were death and/or recurrent CHF presentation over a median follow-up period of 1 year.

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