What are the clinical findings of the Rothenburger et al study related to the efficacy of brain natriuretic peptide (BNP) assays?

Updated: Jan 08, 2018
  • Author: Donald Schreiber, MD, CM; Chief Editor: Erik D Schraga, MD  more...
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German researchers evaluated NT-proBNP levels in 550 extremely ill patients with severe dilated cardiomyopathy in whom cardiac transplantation was being considered. [52] All patients underwent extensive cardiac evaluation, including echocardiography and right heart catheterization.

The annual mortality rate was predicted by using the NT-proBNP level. At 1 year, patients with levels less than 1000pg/mL had a less than 1% mortality rate, patients with levels of 1000-5000 pg/mL had a 2% mortality rate, and patients with levels greater than 5000 pg/mL had a 28% mortality rate.

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