What are the findings of the Copenhagen Hospital Heart Failure study related to the efficacy of brain natriuretic peptide (BNP) assays?

Updated: Jan 08, 2018
  • Author: Donald Schreiber, MD, CM; Chief Editor: Erik D Schraga, MD  more...
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In the Copenhagen Hospital Heart Failure study, on multivariate analysis, NT-proBNP level was predictive of 1-year mortality in patients with heart failure, but left ventricular ejection fraction (LVEF) and NYHA class were not.

In the study, 1-year mortality was evaluated in 2230 consecutively hospitalized patients. [51] Study patients underwent an assessment of cardiac status on admission, with clinical examination, echocardiography, and measurement of NT-proBNP values.

Heart failure was diagnosed in only 161 patients, but their 1-year mortality rate was 30%. On univariate analysis, LVEF, NYHA class, and NT-proBNP level were independently highly predictive of 1-year mortality. However, on multivariate analysis, only the NT-proBNP level was statistically significant. LVEF provided no additional prognostic value over NT-proBNP values in this small subset of patients with heart failure.

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