What are the signs of advanced peripheral vascular disease (PVD)?

Updated: Dec 31, 2017
  • Author: Everett Stephens, MD; Chief Editor: Erik D Schraga, MD  more...
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Advanced PVD may manifest as mottling in a "fishnet pattern" (livedo reticularis), pulselessness, numbness, or cyanosis. Paralysis may follow, and the extremity may become cold; gangrene eventually may be seen. Poorly healing injuries or ulcers in the extremities help provide evidence of preexisting PVD.

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