What factors affect the severity of an acute manifestation of peripheral vascular disease (PVD)?

Updated: Dec 31, 2017
  • Author: Everett Stephens, MD; Chief Editor: Erik D Schraga, MD  more...
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The site of occlusion, the presence of collateral circulation, and the nature of the occlusion (thrombus or embolus) determine the severity of the acute manifestation. Emboli tend to carry higher morbidity because the extremity has not had time to develop collateral circulation. Whether caused by embolus or thrombus, occlusion results in both proximal and distal thrombus formation as a consequence of flow stagnation.

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