What is the role of class III antiarrhythmics in the treatment of atrial flutter?

Updated: Nov 09, 2018
  • Author: Jesse Borke, MD, FACEP, FAAEM; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Class III antiarrhythmic agents establish a chemical conversion to sinus rhythm.

Intravenous amiodarone has been shown to slow the ventricular rate and is considered as effective as digoxin. Amiodarone has less negative inotropy than calcium channel blockers or beta blockers and can be used in patients with hemodynamic compromise. However, this drug can convert an atrial flutter to normal sinus rhythm—and this may have thromboembolic risk.

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