Which medications in the drug class Nonsteroidal Anti-inflammatory Drugs are used in the treatment of Superficial Thrombophlebitis?

Updated: Apr 17, 2019
  • Author: Khanjan H Nagarsheth, MD, MBA; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Nonsteroidal Anti-inflammatory Drugs

Along with LMWHs, nonsteroidal anti-inflammatory drugs (NSAIDs) are considered first options to resolve symptoms and prevent extension of thromboembolism.

Ibuprofen (Ibu, Advil, Motrin)

Ibuprofen is the drug of choice for patients with mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Indomethacin (Indocin)

Indomethacin, which inhibits prostaglandin synthesis, is rapidly absorbed. Metabolism of the drug occurs in the liver by demethylation, deacetylation, and glucuronide conjugation.

Naproxen (Aleve, Anaprox, Naprelan, Naprosyn)

Naproxen inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in decrease of prostaglandin synthesis.


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