What are the risk factors for venous thromboembolic disease?

Updated: Apr 17, 2019
  • Author: Khanjan H Nagarsheth, MD, MBA; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Other recognized markers of risk for venous thromboembolic disease include the following:

  • Varicose veins
  • Obesity
  • Age older than 60 years (however, there are fewer complications in this age group)
  • Cigarette smoking
  • IV drug abuse
  • Hypercoagulable states (eg, factor V Leiden mutation, prothrombin gene mutation, and protein S deficiency)
  • Systemic lupus erythematosus
  • Acquired immunodeficiency syndrome (AIDS) - Lupus anticoagulant
  • Drug-induced lupus anticoagulant
  • Antithrombin III deficiency
  • Behçet disease
  • Blood type A
  • Burns
  • Catheters (indwelling venous infusion catheters)
  • Chemotherapy
  • Congestive heart failure
  • Estrogen replacements (high dose only)
  • Fibrinogen abnormality
  • Fractures
  • Hemolytic anemias
  • Heparin-associated thrombocytopenia
  • Homocysteinemia
  • Homocystinuria
  • Hyperlipidemias
  • Immobilization
  • Malignancy
  • MI
  • Phenothiazines
  • Plasminogen abnormality
  • Plasminogen activator abnormality
  • Polycythemia
  • Postoperative
  • Protein C deficiency
  • Protein S deficiency
  • Resistance to activated protein C
  • Thrombocytosis
  • Trauma
  • Ulcerative colitis
  • Venography
  • Venous pacemakers
  • Venous stasis
  • Warfarin - First few days of therapy
  • Caustic materials, such as lighter fluid, injected intravenously [8]

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